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Full Publication List

Li Y, Martin LD, Spizz G, Adler KB: MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 276:40982 40990, 2001.

Petersen, CA and Adler KB: Airways inflammation and COPD: Epithelial neutrophil interactions. Chest 121:142S 150S, 2002.

Singer M, Martin LD, Vargaftig BB, Park J, Gruber AD, Li Y, Adler KB. A MARCKS related peptide blocks mucus hypersecretion in a murine model of asthma. Nature Medicine 10:193 196; 2004.

Takashi S, Park J, Fang S, Parikh I, Koyama S, Adler KB: A Peptide against the N terminus of MARCKSinhibits degranulation of human leukocytes in vitro. Am J Resp Cell Molec Biol 34:647 652, 2006.

Agrawal A, Rengarajan S, Adler KB, Ram A, Ghosh B, Fahim M, Dickey BF: Inhibition of mucin secretion with MARCKS related peptide improves airflow obstruction in a mouse model of asthma. J Appl Physiol 102:399 405, 2007.

Park J A, Adler KB: Potential therapy for mucus hypersecretion in COPD. J Org Dysfunction 3: 66 71, 2007.

Park J A, Park JJ, Fang S, Crews AL, Lampe WR, Adler KB: Protein Kinase C ? regulates mucin secretion via phosphorylation of MARCKS protein in human airway epithelial cells in vitro. Am J Pathol , 171:1822 1830, 2007.

Park JJ*, Fang S*, Crews AL, Lin K W, Adler KB: MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins. *Co first authors. Am J Resp Cell Mol Biol 102:949 955, 2008.

Eckert RE, Neuder LE, Park J, Adler KB, Jones SL.: Myristoylated Alanine Rich C kinase Substrate (MARCKS) Protein Regulation of Human Neutrophil Migration in vitro. Am J Resp Cell Molec Biol , 42:586 594, 2010.

Lin K W, Park j, Fang S, Crews AL, Adler KB: MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells. Am J Resp Cell Molec Biol , 43: 131 136, 2010.

Miller JF, Lankford SM, Adler KB, Brody AR: Mesenchymal Stem Cells require MARCKS Protein for Directed

Agrawal A, Murphy EC III, Park J, Adler KB, Parikh I: Aerosolized BIO 11006, a novel MARCKS related peptide, improves airway obstruction in a mouse model of mucus hypersecretion. J Epith Biol Pharmacol , 3: 13 20, 2011.

Green T, Crews AL, Park J, Fang S, Adler KB: Regulation of mucin secretion and inflammation in asthma; A role for MARCKS protein? Biochim Biophys Acta 1810;1110 1113, 2011.

Raiford KL, Park JJ, Lin KW, Fang S, Crews AL, Adler KB: Mucin granule associated proteins in human bronchial epithelial cells; the airway goblet cell “ granulome ”. Resp Res, 12:118 127, 2011.

Green T, Park JJ, Qi Y, Fang S, Crews AL, Jones SL, Adler KB: Directed migration of mouse macrophages in vitro involves myristoylated alanine rich C kinase substrate (MARCKS) protein. J Leuk Biol , 92:633 639, 2012.

Ott LE*, Sung EJ*, Melvin AT, Sheats MK, Haugh JM, Adler KB, Jones SL: Fibroblast migration is regulated by Myristoylated Alanine Rich C Kinase Substrate (MARCKS) Protein. (*co first authors) PLoS One 2012;June 19; 8(6): e66512.

Li J, D’Annibale Tolhurst MA, Adler KB, Fang S, Yin Q, Birkenheuer AJ, Levy MG, Jones SL, Sung EJ, Hawkins E, Yoder JA, Nordone SK: A MARCKS related peptide suppresses cytokine mRNA and protein expression in LPS activated canine neutrophils. Am J Resp Cell Molec 48:314 321, 2013.

Fang S, Park JJ, Crews AL, Chen W, Adler KB: MARCKS and HSP70 interactions regulate mucin secretion by human
airway epithelial cells in vitro. Amer J Physiol : Lung Cell Mol Physiol 304:L511 L518, 2013.

Adler KB, Tuvim MJ, Dickey BF: Regulated mucin secretion from airway epithelial cells. Frontiers Neuroendocrine Sci. Sep 18; 4:129. eCollection . doi:10.3389/fendo.2013.00129, 2013

Chen CS, Thai P, Yoneda K, Adler KB, Yang P C, Wu R: A peptide that inhibits function of Myristoylated Alanine Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene: 33:3696 3706, 2014.

Chen CS, Chiu CL, Adler KB, Wu R: A novel predictor of cancer malignancy and potential therapeutic target: Up regulation of MARCKS phosphorylation in lung cancer. Am J Resp Crit Care Med; 189, 1002 1004, 2014.

Sheats MK, Pescosolido KC, Hefner EM, Sung EJ, Adler KB, Jones SL: Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to rmbeta2 integrin dependent responses of equine neutrophils.
Veterinary Immunology Immunopathology 160:167 176, 2014.

Chen CS, Statt S, Thai P, Arif M, Chiu CL, Adler KB, Wu R: Targeting the MARCKS phosphorylation site domain in lung cancer: Mechanisms and therapeutic implications. American Journal of Respiratory and Critical Care Medicine 190:1127 1138, 2015.

Sheats MK*, Sung EJ*, Adler KB, Jones SL: In vitro neutrophil migration requires protein kinase c delta ( ? PKC) mediated MARCKS ( Myristoylated Alanine Rich C Kinase Substrate) phosphorylation. (* Co first authors). Inflammation 38:1126 1141, 2015.

Muthusamy N, Sommerville LJ, Moeser AJ, Stumpo DJ, Sannes PL, Adler KB, Blackshear PJ, Jill M, Weiner JM, Ghashghaei HT: MARCKS dependent mucin clearance and lipid metabolism in ependymal cells is required for maintenance of forebrain homeostasis during aging. Aging Cell 14: 764 73, 2015.

Yin Q*, Fang S*, Park J, Crews A, Parikh I, Adler KB: An Inhaled Inhibitor of MARCKS Reverses LPS induced Acute Lung Injury in Mice”. (* Co first authors) Am J Resp Cell Mol Biol 55: 617 622, 2016.

Brudvig JJ, Cain JT, Sears RM, Schmidt Grimminger GG, Wittchen ES, Ghashghaei HT, Adler KB, Weimer JM. MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. Scientific Reports 8:13278, 2018.

Sheats MK, Yin Q, Fang S, Park J, Crews AL, Parikh I, Dickson B, Adler KB. Adler KB: MARCKS protein and Lung Disease. Am J Respir Cell Mol Biol 60:16 27, 2019.

Fang S, Yin Q, Crews A, Park J, Parikh I, Dickson B, Adler KB: Inhibition of lung cancer metastasis in mice by inhaled aerosolized anti MARCKS peptide. (In Preparation).

Li Y, Pettersen CA, Martin LD, Adler KB: MARCKS protein interaction with the cellular contractile machinery may regulate mucin secretion by human airway epithelium. Am J Resp Crit Care Med: 163:A225, 2001.

Martin LD, Adler KB, Akley NJ, Crews A, Sharova L: Secretion competent tracheal epithelial cell culture from the genetically altered mouse. Chest. 121:1S, 2002.

Vargaftig B, Singer M, Martin LD, Li Y, Adler KB: A myristoylated peptide directed against the N terminal region of MARCKS protein inhibits mucin secretion in ovalbumin sensitized/challenged mice in vivo. Am J Resp Crit Care Med 167:A17, 2003.

Park J, Fang S, Gruber AD, Adler KB: MARCKS protein interaction with the “secretory module” regulates airway mucin secretion. Am J Resp Crit Care Med 169:A535, 2004.

Fang S, Park J, Adler KB: Small interfering RNA’s directed against MARCKS protein and Heat Shock Protein 70 (Hsp70) attenuate mucin secretion in human airway epithelial cells in vitro. Am J Resp Crit Care Med 169:A712, 2004.

Takashi S, Pettersen CA, Park J, Fang S, Akley NJ, Adler KB: A Peptide directed against the N terminus of MARCKS protein attenuates release of myeloperoxidase (MPO) from human and canine neutrophils in vitro. Proc Am Thoracic Soc , 2: A633,

Agrawal A, Subramannian R, Adler KB, Ram A, Ghosh B, Farim M, Dickey BF: MARCKS related peptide improves airway obstruction related to mucus secretion in a mouse model of asthma. Proc Am Thoracic Soc 3:A713, 2006.

Green TD, Eckert BS, Sharief Y, Crews AL, Adler KB, Jones SL. A peptide against the N terminus of MARCKS protein attenuates leukocyte migration. Proc Am Thoracic Soc 175:A915, 2007.

Park JA, Crews AL, Adler KB: Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein. Proc Am Thoracic Soc 175: A752, 2007.

Raiford KL, Lin KW, Park J, Fang S, Crews AL, Adler KB: Proteomic analysis of mucin granule membrane associated proteins in human airway epithelial cells: a mechanistic link between MARCKS and hClCA1? Proc Am Thoracic Soc 175:A511, 2007

Panetteiri RA, Jester WF, Jiang M, Zhao H, Liang J, Parikh I, Murphy T, Adler KB: Inhibition of ozone induced airway inflammation by decreasing myristoylated alanine rich C kinase substrate function. Am J Resp Crit Care Med 177:A495, 2008

Wang Y, Adler K, Slade DJ, Church TD, Webb RF, Chu HW, Jinwright D, Crews A, Kraft M. A MARCKS related Peptide Inhibits MUC5AC expression in Airway Epithelial Cells Isolated From Asthmatic Subjects. Am J Resp Crit Care Med, 177: A814, 2008.

Crews AL, Potts E, Voynow JA, Fischer BM, Bumgardner S, Adler KB, Foster WM: A MARCKS related peptide attenuates both mucin hypersecretion and inflammatory cell infiltration in an elastase model of chronic bronchitis. Am J Resp Crit Care Med, 177:A332, 2008.

Lin K, Park JJ, Fang S, Adler KB: MARCKS protein regulation of mucin secretion in airway epithelial cells: binding of MARCKS to chaperones and to MyosinV . Am J Resp Crit Care Med, 177:A993, 2008.

Raiford KL, Adler KB: A proteomic analysis of proteins associated with mucin granule membranes within airway epithelial cells. Am J Resp Crit Care Med, 177:A993, 2008.

Fang S, Crews AL, Chen W, Ren XR, Adler KB: Interactions between MARCKS and the chaperone Hsp70 in airway epithelium. Am J Resp Crit Care Med 179:A6292, 2009.

Green TD, Park J, Jones SL, Adler KB: A MARCKS related peptide inhibits migration of murine macrophages. Am J Resp Crit Care Med 179:A1346 , 2009.

Green TD, Adler KB: The Role of Marcks Related Peptide In Migration Of Primary Murine Macrophages. Am J Resp Crit Care Med 183:A4542, 2011.

Lampe WR, Adler KB: Inhibition of Calpain reduces mucus secretion in airway epithelial cells, potentially through cleavage of MARCKS protein. Am J Resp Crit Care Med 183:A1220, 2011.

Yin Q, Lampe WR, Fang S, Crews A, Yin J, Adler KB: Enhanced Expression of Myristoylated Alanine Rich C Kinase Substrate (MARCKS) in Airway Epithelium of an Animal Model of Allergic Airway Inflammation and Human Patients with COPD. Am J Resp Crit Care Med 185:A1281, 2012.

Li J, D’Annibale MA, Adler KB, Birkenheuer AJ, Levy MG, Yoder JA, Jones SL, Nordone SK: MARCKS protein plays a critical role in production of proinflammatory cytokines by isolated canine neutrophils Am J Resp Crit Care Med 185:A2106, 2012.

Fang S, Yin J, Yin Q, Crews AL, Adler KB: Myristoylated Alanine Rich C Kinase Substrate (MARCKS) Inhibitory Peptides Attenuate Lipopolysaccharide (LPS) Induced NF ? B Activation and Subsequent Interleukin 8 (IL 8) Production by Human Airway Epithelial Cells in vitro. Am J Resp Crit Care Med 185:A1346, 2012.

Yin Q, Lampe WR, Fang S, Park JJ, Crews AL, Adler KB: MicroRNA 21 downregulates expression of MARCKS and mucin after LPS exposure in vivo and in vitro. Am J Resp Crit Care Med 187;A3434, 2013.

Fang S, Lampe WR, Yin Q, Crews AL, Adler KB: MicroRNA 21 regulates expression of MARCKS and inflammatory genes in human airway epithelial cells in response to LPS. Am J Resp Crit Care Med 187;A4740, 2013.

Park J, Fang S, Yin Q, Crews AL, Adler KB: MARCKS binding to membrane phosphoinositide bisphosphate (PIP2) is involved in migration of lung cancer cells. Am J Resp Crit Care Med 189; A5410, 2014.

Yin Q, Fang S, Park J, Crews AL, Adler KB: LPS induced acute lung injury in mice is reversed by inhalation of aerosolized peptides that inhibit function of MARCKS protein. Am J Resp Crit Care Med 189; A5329, 2014.

Fang S, Yin Q, Park J, Crews AL, Adler KB: MicroRNA 21 (miR 21) affects migration of human lung cancer cells in vitro via regulation of MARCKS expression. Am J Resp Crit Care Med 189; A3549, 2014.

Yin Q, Crews A, Fang S, Park J, Parikh I, Long W, Chen CH, Wu R, Adler KB: Inhibition of lung cancer metastasis in mice by inhaled aerosolized anti MARCKS peptides Am J Resp Crit Care Med 191; A2429, 2015.

Yin Q, Crews A, Fang S, Park J, Parikh I, Adler KB: Administration of inhaled anti MARCKS peptides reverses LPS induced Acute Lung Injury in mice. Am J Resp Crit Care Med 191; A3923, 2015.

Fang S, Yin Q, Park J, Crews A, Dickson B, Adler KB: Synergy between anti MARCKS peptides and chemotherapeutic agents in attenuation of NSCLC metastasis and tumor growth could be based on MARCKS cell cycle regulation. Am J Resp Crit Care Med 193; A3131, 2016.

Park J, Fang S, Yin Q, Crews AL, Adler KB: Modulation of FAK activity by MARCKS is involved in migration of lung cancer cells. Am J Resp Critl Care Med 193; A2365, 2016.

Yin Q, Fang S, Park J, Crews A, Parikh I, Dickson B, Adler KB: MARCKS inhibitory peptides synergize with cisplatin to inhibit metastasis and primary tumor growth in mouse orthotopic lung cancer models. Am J Resp Critl Care Med 193, A3135, 2016.

Yin Q, Fang S, JJ Park JJ, AL Crews AL, Dickson B, Parikh I, Adler KB: An inhibitor of MARCKS Protein Attenuates Migration of Human Lung Cancer cells; role of Protein Phosphatase Type 2A (PP2A). Am J Resp Critl Care Med 195:A2357, 2017.

Fang S, Yin Q, Park JJ, Crews AL, Dickson B, Adler KB: A Peptide Inhibitor of MARCKS Protein Attenuates Migration of Human Lung Cancer Cells; Cytoskeletal Rearrangement upon Treatment Indicates a Shift from Motile to Structural Cells. Am J Resp Critl Care Med 195:A2358, 2017.

Dickson B, Parikh I, Adler KB: A Placebo Controlled Clinical Study of a MARCKS Inhibitory Peptide in the Treatment of Established ARDS. Proc 5th International ARDS Conference, Berlin, Germany, June 2019