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The MARCKS Protein / MOA

The MARCKS Protein plays an important role in the regulation of inflammation, secretion, cell motility and cell cycle

  • Bound to the cell membrane in its dephosphorylated state by ionic interactions between PSD site
    and membrane phospholipids + insertion into membrane of N terminal Myristic Acid (MA)
  • Phosphorylation site domain (PSD) is site of phosphorylation, actin binding, and calcium /
    calmodulin binding
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BIO-11006 dephosphorylates MARCKS, inhibiting the migration of inflammatory cells